TREATMENT OF PSORIATIC ARTHROPATHY WITH EITHER AZATHIOPRINE OR METHOTREXATE

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Abstract
The response of 10 patients treated with azathioprine (2.5 mg./kg./day) and 5 with methotrexate (10–25 mg. weekly orally) for severely active psoriatic arthropathy has been assessed clinically during a follow-up period of 4½–67 months. The improvement in the arthritis was assessed as excellent or good in 9 of those receiving azathioprine and 4 receiving methotrexate, without relapse during the period of observation. In 6 of 10 patients with psoriasis involving more than 70% of the body surface the skin lesions almost completely cleared, although fluctuation of severity of the skin lesions continued necessitating regular topical treatment. Treatment was discontinued in 4 patients: in 3 because of gastrointestinal disturbances (2 taking azathioprine and 1 methotrexate) and in 1 due to a mild thrombocytopenia while taking azathioprine.

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