Relation of Number of Transplants to Total Volume of Regenerating Adrenocortical Tissue.

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Abstract
Total volume of adrenocortical tissue regenerating in intramuscular autotransplants in rats during the first 2 weeks is proportional to number of transplants growing. Thereafter, total volume is about the same irrespective of the number of implants made or transplants regenerating, so volumes per transplant are inversely proportional to number of grafts. Average volume of regenerating tissue and cell depth increases with increasing age of transplant. At 90 days after operation, cell depth is similar to that of intact adrenal glands but volume is less. Apparently transplants cannot deliver enough cortical secretion to establish a pituitary-adrenal equilibrium during the first 2 weeks while they are progressively resuming function. After that equilibrium becomes established, imperfectly at 21 days but completely at 90 days, and the amount of regenerated tissue becomes a function of time rather than of number of regenerating masses.