A NEW SERIES OF POTENT ANALGESICS: Dextro 2:2-diphenyl-3-methyl-4-morpholinobutyrylpyrrolidine and related basic amides: Part II :Comparative analgesic activity, acute toxicity and tolerance development in rats for R875, morphine, pethidine and methadone
- 1 September 1958
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 10 (1) , 14-21
- https://doi.org/10.1111/j.2042-7158.1958.tb10268.x
Abstract
The analgesic activity, acute toxicity and development of tolerance of R875, morphine, pethidine and methadone after subcutaneous administration in rats have been measured. In this animal, R875 is shown to be several times more active than the three other compounds. R875 has a faster onset of action, higher therapeutic ratios and a slower rate of development of tolerance.Keywords
This publication has 2 references indexed in Scilit:
- A New Series of Potent AnalgesicsJournal of Pharmacy and Pharmacology, 1957
- A NEW SERIES OF POTENT ANALGESICSJournal of the American Chemical Society, 1956