In vitro Activity of Chloramphenicol Combined with Cephalothin against DNase-Positive, Multiple-Antibiotic Resistant Strains of Staphylococcus epidermidis

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Abstract
Six strains of multiple-antibiotic resistant, DNase-positive Staph. epidermidis were found to be sensitive to chloramphenicol and gentamicin sulfate; although cephalothin alone was ineffective, the combination of chloramphenicol and cephalothin resulted in an additive effect against four of the isolates in vitro. However, two strains proved refractory to the combination of these two drugs, emphasizing the need for careful in vitro antibiotic sensitivity studies, especially so in the case of multiple-drug resistant organisms.

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