Therapy of Cervical Chlamydial Infection

Publisher Website
Google Scholar
Abstract
The treatment of cervical Chlamydia trachomatis infection in nonpregnant women was evaluated in a double-blind randomized study. Objective criteria were used to assess the response of cervicitis to therapy. Fifty patients were treated with tetracycline hydrochloride, 500 mg orally 4 times daily and 50 patients were treated with rosaramicin, 250 mg orally 4 times daily, both for 7 days. Both agents were highly effective in eradicating C. trachomatis. Both produced significant improvement in objective signs of cervicitis: eliminating mucopurulent endocervical discharge and edema of ectopy, and decreasing the clinical severity score of cervicitis. This trial shows that the 1-wk course of tetracycline hydrochloride currently recommended for treatment of chlamydial urethritis in men is also highly effective for the treatment of chlamydial cervical infection in women. Rosaramicin, a macrolide antibiotic, was equally effective, but produced a higher rate of gastrointestinal side effects.