Influences of clotting factors (thrombin, factor XIII) and of fibronectin on the growth of tumor cells and leukemic cells in vitro
- 1 February 1983
- journal article
- Published by Springer Nature in Annals of Hematology
- Vol. 46 (2) , 85-88
- https://doi.org/10.1007/bf00320663
Abstract
Thrombin, factor XIII and fibronectin were incubated with cultures of mouse sarcoma cells, human cervix carcinoma cells (HeLa cells) and cells of an acute lymphoblastic leukemia. Thrombin induced a significant increase of 3H-thymidine uptake into cells with a 1,5- to 2-fold increase of cell count. The cells of an acute lymphoblastic leukemia showed a similar response to the influence of thrombin. Factor XIII in tumor cells merely induced an increase of 3H-thymidine uptake, the cell count remained constant. The cells of an acute lymphoblastic leukemia showed under the influence of factor XIII a significant increase of cell count and thymidine uptake. HeLa cell growth was optimal at low fibronectin concentrations. Fibronectin concentrations of 1 mg/ml to 3 mg/ml inhibited HeLa and mouse sarcoma cell growth.Keywords
This publication has 5 references indexed in Scilit:
- Growth regulation of fibroblasts by thrombin, factor XIII and fibronectinKlinische Wochenschrift, 1981
- Cell-Surface FibronectinPublished by American Medical Association (AMA) ,1980
- Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pitsProceedings of the National Academy of Sciences, 1979
- Angewandte StatistikPublished by Springer Nature ,1978
- Characterization of EBV‐genome negative “null” and “T” cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non‐Hodgkin lymphomaInternational Journal of Cancer, 1977