Buccal and Percutaneous Absorptions
- 1 February 1971
- journal article
- research article
- Published by SAGE Publications in Drug Intelligence & Clinical Pharmacy
- Vol. 5 (2) , 38-41
- https://doi.org/10.1177/106002807100500202
Abstract
Buccal absorption of 31 aromatic and aliphatic acids and 10 basic drugs in human subjects has been found to be parabolically dependent on the log P, where P is the l-octanol-water partition coefficient. The ideal lipophilic character (log Po) for maximum buccal absorption is found to range from 4.2 to 5.5. The log of the permeability constant of a series of alcohols and steroids has been found to be linearly dependent upon the log of the partition coefficient measured in three different solvent systems.Keywords
This publication has 15 references indexed in Scilit:
- Physicochemical Properties and Gastrointestinal Absorption of DrugsDrug Intelligence & Clinical Pharmacy, 1970
- Correlation of partition coefficients in n-heptane-aqueous systems with buccal absorption data for a series of amines and acidsJournal of Pharmacy and Pharmacology, 1969
- The influence of substitution in phenylacetic acids on their performance in the buccal absorption testJournal of Pharmacy and Pharmacology, 1969
- Percutaneous Absorption of SteroidsJournal of Investigative Dermatology, 1969
- The influence of alkyl substitution in acids on their performance in the buccal absorption testJournal of Pharmacy and Pharmacology, 1968
- Mechanism of Percutaneous AdsorptionJournal of Investigative Dermatology, 1965
- 256. The mechanism of the antibacterial action of phenols and salicylaldehydes. Part II. Substituted phenolsJournal of the Chemical Society, 1964
- Mechanisms of Drug Absorption and DistributionAnnual Review of Pharmacology, 1961
- Some Physico-Chemical Factors in Drug ActionJournal of Pharmacy and Pharmacology, 1957
- The Partition of Organic Compounds Between Higher Alcohols and Water.Acta Chemica Scandinavica, 1951