High performance liquid chromatographic determination of 5-fluorocytosine in human serum
- 1 April 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 7 (4) , 363-369
- https://doi.org/10.1093/jac/7.4.363
Abstract
A chemical method for determination of 5-fluorocytosine in serum is described. After extraction with acetonitrile, the drug was separated by ion-pair reverse-phase high performance liquid chromatography and detected by absorption at 254 nm. The method is rapid, specific and precise. Comparison with a microbiological method showed good correlation.Keywords
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