Results of a Cooperative Study on the Precision of Liquid Chromatographic Measurements at Low Signal-to-Noise Ratios

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Abstract
A cooperative study evaluating the precision of inter-laboratory liquid chromatographic (LC) measurements at low signal-to-noise levels is reported. Three aspects are of particular interest: an examination of the variation in precision with peak size, a comparison between the precision of area and height measurements at low signal-to-noise levels, and a comparison between the precision obtained with fixed and variable wavelength UV absorbance detectors. The best overall precision is noted for peak area measurements with fixed wavelength detectors. A decrease in the precision of peak area measurements is observed for variable wavelength detectors compared with that of fixed wavelength detectors. This difference is not observed with peak height measurements.

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