Synergistic Killing of Streptococcus pneumoniae with the Bacteriophage Lytic Enzyme Cpl-1 and Penicillin or Gentamicin Depends on the Level of Penicillin Resistance
Open Access
- 1 March 2005
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (3) , 1225-1228
- https://doi.org/10.1128/aac.49.3.1225-1228.2005
Abstract
A combination of Cpl-1, a bacteriophage lytic enzyme, and penicillin, gentamicin, levofloxacin, or azithromycin was tested against Streptococcus pneumoniae strains with various susceptibilities to penicillin. Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicillin MIC, while Cpl-1 and penicillin showed synergy against an extremely penicillin-resistant strain.Keywords
This publication has 11 references indexed in Scilit:
- Phage lytic enzymes as therapy for antibiotic-resistant Streptococcus pneumoniae infection in a murine sepsis modelJournal of Antimicrobial Chemotherapy, 2003
- Phage Lytic Enzyme Cpl-1 as a Novel Antimicrobial for Pneumococcal BacteremiaInfection and Immunity, 2003
- Synergistic Lethal Effect of a Combination of Phage Lytic Enzymes with Different Activities on Penicillin-Sensitive and -Resistant Streptococcus pneumoniae StrainsAntimicrobial Agents and Chemotherapy, 2003
- A bacteriolytic agent that detects and kills Bacillus anthracisNature, 2002
- Rapid Killing of Streptococcus pneumoniae with a Bacteriophage Cell Wall HydrolaseScience, 2001
- The Role ofmurMNOperon in Penicillin Resistance and Antibiotic Tolerance ofStreptococcus pneumoniaeMicrobial Drug Resistance, 2001
- Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzymeProceedings of the National Academy of Sciences, 2001
- Carriage of Internationally Spread Clones ofStreptococcus pneumoniaewith Unusual Drug Resistance Patterns in Children Attending Day Care Centers in Lisbon, PortugalThe Journal of Infectious Diseases, 2000
- Bacteriophages ofStreptococcus pneumoniae:A Molecular ApproachMicrobial Drug Resistance, 1997
- Penicillin Tolerance in Multiply Drug-Resistant Natural Isolates of Streptococcus pneumoniaeThe Journal of Infectious Diseases, 1985