THE c‐WAVE OF THE HUMAN ELECTRORETINOGRAM IN CENTRAL RETINAL ARTERY OCCLUSION

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Abstract
The pigment epithelium‐receptor complex, which is supplied from the choroidal circulation, is the main source of the c‐wave of the ERG. Occlusion of the central retinal artery (OCRA), which causes serious damage to the inner retinal layers, should therefore not primarily be expected to affect the c‐wave amplitude. Nevertheless, conflicting reports of increased, decreased and unchanged c‐waves have appeared in the literature. In the present study on four patients with OCRA the affected eyes showed diminished b‐ and c‐waves. On the other hand, both the a‐wave and the trough between the b‐ and c‐waves were accentuated in the diseased eyes. Experiments in progress on Cynomolgus monkeys with experimentally induced unilateral OCRA show similar results.