Nesting: hierarchies of allosteric interactions.
- 1 April 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (7) , 1891-1895
- https://doi.org/10.1073/pnas.84.7.1891
Abstract
A generalization of the allosteric model is presented that incorporates a hierarchy of conformational equilibria. Such a formulation draws upon structural organization already seen in many large macromolecular systems. The functional binding properties of the macromolecule reflect conformational equilibria at each structural level. Appropriate "nested" models are used to interpret structural features and functional aspect of two hemocyanin systems with a large number (12 and 24) of binding sites.This publication has 16 references indexed in Scilit:
- Oxygen-binding characteristics of Potamilla chlorocruorinEuropean Journal of Biochemistry, 2008
- Cooperative free energies for nested allosteric models as applied to human hemoglobinBiophysical Journal, 1986
- Binding of oxygen and carbon monoxide to arthropod hemocyanin: an allosteric analysisBiochemistry, 1985
- Thin-layer fluorescence cell for ligand binding studiesAnalytical Biochemistry, 1983
- Allosteric properties and the association equilibria of hemocyanin from Callianassa californiensisJournal of Molecular Biology, 1979
- Analysis of the effect of three different allosteric ligands on oxygen binding by hemocyanin of the shrimp, Penaeus setiferusBiochemistry, 1978
- Oxygen binding by Callianassa californiensis hemocyaninBiochemistry, 1974
- Subunit interactions of lobster hemocyaninArchives of Biochemistry and Biophysics, 1971
- On the nature of allosteric transitions: A plausible modelJournal of Molecular Biology, 1965
- The binding potential, a neglected linkage conceptJournal of Molecular Biology, 1965