STUDIES ON THE HEMODYNAMIC ACTION OF SUBCUTANEOUSLY INJECTED EPINEPHRIN

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Abstract
Small dogs under par-aldehyde or morphine were employed. When large doses of epinephrine were injected subcutaneously a pressor action followed, as a rule, only after massage of the injected area. Repetition of the massage caused repeated pressor effects. A pressor effect was obtained by massaging 19 hrs. after the injection. Profound anesthesia militated against the occurrence of a pressor effect; light anesthesia or peripheral dilatation (by nitrites) increased the speed and magnitude of the response.

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