Cimoxatone Is a Reversible Tight‐Binding Inhibitor of the A Form of Rat Brain Monoamine Oxidase
- 1 February 1983
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 40 (2) , 510-513
- https://doi.org/10.1111/j.1471-4159.1983.tb11312.x
Abstract
Cimoxatone is a fully reversible inhibitor selective for the A form of monoamine oxidase. The inhibition is so potent against this enzyme form that it acts as a tight-binding inhibitor. Use of this inhibitor indicates that in rat brain homogenates the concentration of monoamine oxidase A is approximately 8-11 pmol/mg protein. Values similar to this were obtained by clorgyline titration, and both methods gave values similar to those found with a [3H]harmaline binding assay.Keywords
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