Axonal Spheroids in the Cochlear Nucleus of Normal Beagle Dogs

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Abstract
In the course of drug evaluation studies, sporadic axonal spheroids were identified in the cochlear nucleus of 8–15-month-old Beagle dogs. These structures were identified by Bielschowski histochemical and anti-neurofilament immunohistochemical stains and by ultrastructural examination. No cellular reaction or significant neuropil alterations were associated with the presence of the spheroids. Their presence was unrelated to treatment and were considered to be an incidental background finding.