Predictions of the antimalarial activity of arylamidinoureas
Open Access
- 1 August 1973
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 48 (4) , 650-654
- https://doi.org/10.1111/j.1476-5381.1973.tb08253.x
Abstract
1 Regression equations were calculated relating the observed antimalarial potencies of arylamidinoureas to their predicted physicochemical properties. 2 A two-parameter equation was used to forecast the antimalarial activity of more arylamidinoureas. 3 Thirteen compounds of the predicted type were synthesized, and their observed antimalarial potencies compared with the forecasts.Keywords
This publication has 5 references indexed in Scilit:
- Prediction of Pharmacological Activity by the Method of Physicochemical—Activity RelationshipsPublished by Elsevier ,1973
- Partition coefficients and their usesChemical Reviews, 1971
- A New Substituent Constant, π, Derived from Partition CoefficientsJournal of the American Chemical Society, 1964
- p-σ-π Analysis. A Method for the Correlation of Biological Activity and Chemical StructureJournal of the American Chemical Society, 1964
- A Reëxamination of the Hammett Equation.Chemical Reviews, 1953