Familial intracranial aneurysms and cerebral vascular anomalies

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Abstract
A family is reported in which 4 members had intracranial aneurysms and 1 additional member was suspect. One member had multiple aneurysms that were successfully treated surgically. Elective angiography on 5 asymptomatic members of the family disclosed asymptomatic aneurysms in 2. In addition, cerebrovascular anomalies were found in many of the family members. The parents of the family were consanguineous. High incidence of these associated anomalies and consanguinity in the parents tend to suggest the hereditary basis of the disease. Banding analysis of chromosomes in 3 siblings with aneurysms and 3 siblings without aneurysms was carried out. Elective investigation of the asymptomatic members should be considered where there are already 2 or more affected in a family. The indications for surgical prophylaxis on asymptomatic aneurysms in other members of the family are discussed.