St. John's Wort
- 1 September 2000
- journal article
- Published by SAGE Publications in The International Journal of Psychiatry in Medicine
- Vol. 30 (3) , 203-219
- https://doi.org/10.2190/pbfd-lwb4-u8cg-53c9
Abstract
Objective: The objective of this article is to review the current knowledge of the pharmacology, sites of action, and therapeutic effectiveness of St. John's Wort. Method: The method used was a review of the available literature, using keywords to search the medline database. Bibliographies of the papers, thus obtained, were searched for further documents not referenced by medline. We reviewed papers from this collection. Results: This review reveals that most of the available data on efficacy and safety of St. John's Wort involve its use in mild to moderate depression. Much, but not all of the prevailing opinion is positive. Nevertheless, the quality of therapeutic trials vary so greatly that definitive conclusions are not possible. Both the source and mode of St. John's Wort's therapeutic effect are unclear. We need further controlled studies of effectiveness, safety, and mode of action. In addition to its use in depression, there are reports suggesting possible therapeutic effects in other conditions such as certain malignancies and infections, but these are far too preliminary to permit any conclusions.Keywords
This publication has 61 references indexed in Scilit:
- An alternative medicine study of herbal effects on the penetration of zona-free hamster oocytes and the integrity of sperm deoxyribonucleic acidFertility and Sterility, 1999
- Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals σ receptor bindingLife Sciences, 1998
- Efficacy and Tolerability of St. John's Wort Extract LI 160 Versus Imipramine in Patients with Severe Depressive Episodes According to ICD-10Pharmacopsychiatry, 1997
- LI 160, an Extract of St. John's Wort, Versus Amitriptyline in Mildly to Moderately Depressed Outpatients - A Controlled 6-Week Clinical TrialPharmacopsychiatry, 1997
- Treatment of Seasonal Affective Disorder (SAD) with Hypericum ExtractPharmacopsychiatry, 1997
- The Effect of Hypericum Extract on Cardiac Conduction as seen in the Electrocardiogram Compared to that of ImipraminePharmacopsychiatry, 1997
- Hypericin and Pseudohypericin: Pharmacokinetics and Effects on Photosensitivity in HumansPharmacopsychiatry, 1997
- Biologically Active and Other Chemical Constituents of the Herb ofHypericum perforatumL.Pharmacopsychiatry, 1997
- Hypericin uptake in rabbits and nude mice transplanted with human squamous cell carcinomas: Study of a new sensitizer for laser phototherapyThe Laryngoscope, 1994
- Clinical trial on Neurapas® versus placebo in patients with mild to moderate depressive symptoms: a placebo-controlled, randomised double-blind study Phase IV: Clinical trialComplementary Therapies in Medicine, 1994