Effect of (+)-Cyanidanol-3 on the Changes in Liver Glutathione Content and Lipoperoxidation Induced by Acute Ethanol Administration in the Rat

Publisher Website
Google Scholar
Abstract
Acute ethanol administration to rats fasted overnight decreased the content of liver glutathione (GSH) and concomitantly increased oxidized glutathione levels, representing a net 38% decrease in total GSH equivalents. Liver lipoperoxidation was significantly enhanced. Treatment with (+)-cyanidanol-3 prior to ethanol ingestion reduced by 80% the ethanol-induced depletion in total GSH equivalents and to completely abolish lipoperoxidation. (+)-Cyanidanol-3 apparently has a protective effect on the changes in liver GSH levels and lipoperoxidation induced by ethanol, probably related to its scavenging action exerted on free radicals.