Maximum likelihood estimation and identification directly from single-channel recordings
- 22 August 1992
- journal article
- Published by The Royal Society in Proceedings Of The Royal Society B-Biological Sciences
- Vol. 249 (1325) , 125-132
- https://doi.org/10.1098/rspb.1992.0094
Abstract
We present a method for analysis of noisy sampled data from a single-channel patch clamp which bypasses restoration of an idealized quantal signal. We show that, even in the absence of a specific model, the conductance levels and mean dwell times within those levels can be estimated. Estimation of the rate constants of a hypothesized kinetic scheme is more difficult. We present examples in which the rate constants can be effectively estimated and examples in which they cannot.Keywords
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