A New Method of Measuring Hydroxyapatite Dissolution Rate

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Abstract
A dissolution cell was constructed for use in measuring the rate of acid dissolution of test surfaces. The initial rate of dissolution in potassium acetate buffer (pH 4.65) of discs of compressed hydroxyapatite can be determined with a coefficient of variation < 1%. The reduction in the rate of dissolution of the hydroxyapatite discs after a 1 min topical application of fluoride solutions or slurries of fluoride toothpaste having concentrations as low as 0.2 ppm F- was easily demonstrable. This test was also sensitive enough to demonstrate fluoride activity after as little as 10 s exposure of the discs to fluoride solutions. Enamel mosaics prepared from human caries-free teeth could also be employed in the dissolution cell. One minute pretreatment of these mosaics with monofluorophosphate toothpastes indicated activity of a similar order to that found using discs of pure hydroxyapatite.

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