THE DISTRIBUTION OF FAT IN THE ENDOMETRIUM OF THE CASTRATE RABBIT AFTER TREATMENT WITH ESTRADIOL BENZOATE AND PROGESTERONE

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Abstract
Castration was associated with the presence of small globules of fat in the stromal cells and a diffuse distribution of fat in the surface epithelium. Estradiol benzoate alone in small quantities did not affect distribution of fat in the stroma but caused disappearance of fat globules from the surface epithelium. Estradiol benzoate in large quantities caused the fat to disappear from the surface epithelium and the fat in the stromal cells was considerably reduced. Progesterone in quantities of 1.5 mg. to 7 mg., not preceded by treatment with estradiol benzoate, caused an appearance of extremely scanty basal fat in occasional gland cells. Large quantities of progesterone (20 mg.) tended to reduce the distribution of basal fat. Progesterone in quantities of 1.5 mg. to 7 mg. resulted in a slight diminution in the amt. of stromal fat while 20 mg. of progesterone diminished the fat in the stromal cells. In rabbits previously sensitized with estradiol benzoate, combinations of estradiol benzoate with adequate quantities of progesterone, which were associated with a +2 progesta-tional response, caused the appearance of abundant fat in the infra-nuclear region of the glandular epithelial cells and in the stromal cells. Combinations of estradiol benzoate and progesterone which were unable to produce progesta-tional responses in the uterus, despite large quantities of progesterone, were associated with an abundance of fat in the supra-nuclear and infra-nuclear region of the surface epithelial cells and in the sub-epithelial stromal cells. The use of these combinations of estradiol benzoate and progesterone was at the same time associated with a marked vascularity of the uterus which might even culminate in necrosis of the endometrium.