Failure of the perioperative PCV neoadjuvant polychemotherapy in resectable bronchogenic non-small cell carcinoma results from a randomized phase II trial
Open Access
- 1 June 1990
- Vol. 65 (11) , 2435-2441
- https://doi.org/10.1002/1097-0142(19900601)65:11<2435::aid-cncr2820651105>3.0.co;2-2
Abstract
In 1985, the authors began a phase II study to assess the PCV perioperative polychemotherapy (cisplatin 100 mg/m2, cyclophosphamide 600 mg/m2, vindesine 3 mg/m2) in patients with resectable bronchogenic non‐small cell carcinoma. Patients were randomized to receive either two preoperative courses of PCV chemotherapy, surgery, and two postoperative courses of PCV chemotherapy (PCV group) or immediate surgery (surgery group). A staging procedure using the CT scan was performed before randomization and, additionally, before surgery in the PCV group. There were 26 randomized patients, 13 in each group. In the PCV group, 11 patients agreed to receive the two preoperative courses of chemotherapy. A response was observed in five patients (45%), and a progression was observed in four patients (36%) leading to a cancellation of surgery in two of them. Postoperative care was the same for each group. Although no death could be related to chemotherapy, it was decided to stop entering new patients into this trial because of the rate of preoperative progression in the PCV group.This publication has 25 references indexed in Scilit:
- In vivo emergence of a highly metastatic tumour cell line from a rat rhabdomyosarcoma after treatment with an alkylating agentBritish Journal of Cancer, 1988
- Surgical adjuvant therapy for stage II and stage III adenocarcinoma and large-cell undifferentiated carcinoma.Journal of Clinical Oncology, 1986
- Chemotherapy of advanced non-small cell lung cancerInvestigational New Drugs, 1984
- Computed tomography in the preoperative evaluation of bronchogenic carcinoma.Radiology, 1982
- Surgical Adjuvant Therapy for Lung CancerSurgical Clinics of North America, 1981
- Surgical adjuvant chemotherapy in non-small cell carcinoma of the lungInternational Journal of Radiation Oncology*Biology*Physics, 1980
- 5-year follow-up of cytotoxic chemotherapy as an adjuvant to surgery in carcinoma of the bronchusBritish Journal of Cancer, 1976
- Unfavourable effects of long-term adjuvant chemotherapy with Endoxan in radically operated bronchogenic carcinomaPublished by Elsevier ,1971
- Study of Cytotoxic Chemotherapy as an Adjuvant to Surgery in Carcinoma of the BronchusBMJ, 1971
- Bronchogenic CarcinomaArchives of Surgery, 1967