Quinolone Resistance Is Associated with Increased Risk of Invasive Illness or Death during Infection withSalmonellaSerotype Typhimurium
Open Access
- 1 November 2004
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 190 (9) , 1652-1654
- https://doi.org/10.1086/424570
Abstract
In a registry-based cohort study, we determined the risk of invasive illness or death associated with infection with quinolone- resistant Salmonella serotype Typhimurium.We linked data from the Danish surveillance registry of enteric pathogens with data from the Danish civil registration system and 2 national health registries. Of 1323 patients infected with Salmonella Typhimurium, 46 (3.5%) were hospitalized due an invasive illness within 90 days of infection, and 16 (1.2%) died within 90 days of infection. After adjustment for age, sex, and comorbidity, infection with quinolone-resistant Salmonella Typhimurium was associated with a 3.15-fold (95% confidence interval, 1.39–7.10-fold) higher risk of invasive illness or death within 90 days of infection, compared with that observed for infection with pansusceptible strains.Keywords
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