Zur Pathologie der Ikterus

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Abstract
A single oral dose of ANIT in rats causes transient jaundice with slightly increased total serum bilirubin and a preponderance of the gamma - over the [beta]-bilirubin fraction. In experimental obstructive jaundice through ligature of the choledochus analogous serum bilirubin values are found. A different mechanism must, however, be held responsible for ANIT jaundice. In the electron microscopic and histo-chemic examination lesions to the liver cell membrane is seen. Active bilirubin excretion into the bile canaliculi is inhibited; the bilirubin retained in the liver cells passes into the sinusoidal space and the blood via submicroscopic cytoplasmatic vesicles.