Acetylcholine and Gastric Secretion

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Abstract
Summary Hemicholinium in conscious dogs with gastric fistulae and Heidenhain pouches depressed PG and 2 deoxy-D-glu-cose stimulation of acid and pepsin secretion. On the other hand, it either augmented or did not significantly change histamine- and pilocarpine-promoted secretion. These results support the view that acetyl-choline is an obligatory mediator of the action of PG at secretory effector sites.

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