ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY (ADCC) AGAINST EPSTEIN-BARR VIRUS-DETERMINED MEMBRANE ANTIGENS .1. REACTIVITY IN SERA FROM NORMAL PERSONS AND FROM PATIENTS WITH ACUTE INFECTIOUS-MONONUCLEOSIS

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 25  (1) , 1-5
Abstract
The capacity of antibodies, directed against EBV[Epstein-Barr virus]-determined membrane antigens (MA), to induce antibody-dependent cellular cytotoxicity (ADCC) against EBV superinfected lymphoid cell lines [human Burkitt''s lymphoma Daudi and Raji cells] was investigated. Such reactive antibodies were found, at high dilutions, in sera from normal EBV-positive persons, but not in sera from EBV-negative persons. Sera from patients with acute infectious mononucleosis (IM), which develop EBV-specific killer T [thymus-derived] cells, did not induce ADCC. The difference in specificity between ADCC and EBV-specific killer T cells is briefly discussed.