INDUCTION OF B-TROPIC AND N-TROPIC MURINE LEUKEMIA-VIRUS FROM B10.BR-SGLI MOUSE EMBRYO CELL-LINES BY 5-IODO-2'-DEOXYURIDINE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 63  (1) , 213-217
Abstract
In contrast to the original B10.BR/SgSn congenic mouse strain, adult mice of the B10.BR/SgLi subline showed a high level of expression of B-tropic ecotropic murine leukemia virus (MuLV). Both B-tropic and N-tropic ecotropic MuLV could be induced in cultures of virus-free cell lines derived from embryos of B10.BR/SgLi mice. Both viruses were also inducible from each of several clonal cell lines and from cultures of F1 embryos of matings of B10.BR/SgLi males with females of strains NFS/N and A/J, which are negative for B-tropic virus. Thus the information for B-tropic MuLV and that for N-tropic MuLV was transmitted as a genetic element in the B10.BR/SgLi subline.