ACTIONS OF OXYTOCIN AND A LONG-ACTING CARBA OXYTOCIN ANALOG ON THE PORCINE MYOMETRIUM INVITRO AND INVIVO

  • 1 January 1979
    • journal article
    • research article
    • Vol. 40  (3) , 430-432
Abstract
The contractile actions of oxytocin and its analog 1-deamino-1-mono-carba-[2-Tyr(OMe)]-oxytocin were compared on in vitro and in vivo preparations of porcine uterine horns. In both experiments, sows in estrus were selected for maximal sensitivity. Despite the loss of peak amplitude associated with the substitution at sequence position 2 of O-methyltyrosine for tyrosine, the 2 remaining alterations (N-terminal deamination and replacement of the 1-6 S-S bridge by CH2S) prolonged the action of single-dose presentations. Instead of having a response lasting minutes when the parent hormone is given, an i.v. dose of about 5 .mu.g of the analog/kg body weight in the intact anesthetized sow resulted in a response lasting 2 h.

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