The Stability of Gastric Acid Secretion during Prolonged Pentagastrin Stimulation in Man

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Abstract
Prolonged stimulation with pentagastrin in doses of 100 and 500 ng/h per kg was performed in 9 healthy subjects. A plateau in gastric secretion was reached after 90 min with 100 ng/h per kg and 500 ng/h per kg resulted in a secretory plateau after 60 min. When the plateau was reached the acid secretion rate was constant for the rest of the study, i.e., 4 h after beginning the pentagastrin infusion. Medians and interquartile ranges of acid output were 4.9 (3.7-5.2) and 8.1 (5.8-9.5) mmol of H+/30 min. No fade of gastric acid secretion evidently occurred during 4 h of submaximal pentagastrin stimulation in normal subjects and the time required for reaching a secretory plateau was dependent on the dose of pentagastrin.

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