Use of 2,5-dichlorophenyl phosphorodichloridothioate in the synthesis of diastereoisomeric dinucleoside phosphorothioates
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 10,p. 591-593
- https://doi.org/10.1039/c39830000591
Abstract
A convenient method for the synthesis, by the phosphotriester approach, of dinucleoside phosphorothioates is illustrated by the preparation and isolation of the pure Rp- and Sp-diastereoisomers of thymidine-3′ thymidine-5′ phosphorothioate (5).Keywords
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