AN ULTRASTRUCTURAL STUDY ON PERIDUCTAL ELASTOSIS IN HUMAN BREAST TUMORS

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Abstract
An ultrastructural study on elastosis of human breast tumors was made with special attention to the periductal elastosis and the cell responsible for elastic fiber formation. The elastosis was prominent in the scirrhous type of duct carcinoma. In the area of mild periductal elastosis, the elastic fibers with many microfibrils and a tiny central elastin were seen around the periductal fibroblasts which were characterized by attenuated cytoplasms with aggregates of microfilaments and slightly developed rough endoplasmic reticulum. With the thickening of the periductal wall, such an area was replaced by abundant mature elastic fibers with peripheral microfibrils and a few intervening ordinary fibroblasts. The periductal fibroblasts which transformed into ordinary fibroblasts during the development of elastosis may be primarily concerned with the elastic fiber formation. In the interlobular tissue in which fibroblasts and myofibroblasts were present, the elastic fibers were larger than those of the periductal area and had less microfibrils in their periphery. The relationship between microfibrils and elastin during the early elastosis, maturation process of the elastic fibers and cell modulation of the fibroblasts in the breast elastosis were discussed.