THE RÔLE OF THE PORTAL SYSTEM IN THE REGULATION OF CIRCULATING BLOOD VOLUME

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Abstract
After rapid intraven. injection of fluid amounting to 50 or 100% of the blood volume in dogs, the blood volume as measured by the dye method is not changed; this confirms Miller and Poindexter. The same is true after transfusions of whole blood. In dogs with Eck fistulae, similar injections of saline or dextrose cause an increase in the blood volume (dye method). Splanchnotomized dogs also show an increase, splenectomized animals do not. If the dye is given prior to the injection of saline, the dilution of dye is comparable to that of the red cells. The action of the portal system as a variable reservoir for blood is discussed on the basis of these results, and the con clusion reached that the portal system is capable of storing a large quantity of blood in such a manner that it is not available for the dilution of dye. Such storage appears to account for the greater part of the injected fluid that does not promptly leave the vessels. The necessary distinction between total and circulating blood volumes is emphasized.

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