Effect of Hemodialysis on Methylprednisolone Plasma Levels

1 January 1977

journal article
research article
Published by S. Karger AG in Nephron

Vol. 18 (4) , 208-211
https://doi.org/10.1159/000180830

Abstract

The effect of hemodialysis on methylprednisolone levels in uremia was investigated [in humans]. Methylprednisolone 15 mg/kg was given i.v. over a period of 20 min to 5 patients undergoing routine maintenance hemodialysis. Dialysis began 5 min after the infusion ended and continued for 5 h. Pre- and post-coil plasma levels and the dialysate level of methylprednisolone were measured at intervals. Dialysance averaged 18.4 .+-. 6.1 ml/min, and mean half-life 149 .+-. 26 min. The volume of distribution was 0.80 of body weight. The significant dialysance of methylprednisolone may require adjustment of dosage in certain clincial situations when hemodialysis is necessary for patients receiving the steroid.

Keywords

This publication has 1 reference indexed in Scilit:

Blood Acid-Base Alignment Nomogram: Scales for pH, pCO₂, Base Excess of Whole Blood of Different Hemoglobin Concentrations, Plasma Bicarbonate, and Plasma Total-CO₂
Scandinavian Journal of Clinical and Laboratory Investigation, 1963