Neurotransmitter Metabolizing Enzymes and Plasma Butyrylcholinesterase in Mice Exposed to Trichloroethylene

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Abstract
Acetylcholinesterase, glutamine synthetase, acid phosphatase and glutamate dehydrogenase activity in brain and cholinesterase activity in blood were investigated in mice exposed to 170 ppm trichloroethylene (TCE) for 30 days. The neuronal enzymes remained unaffected which suggested that no general damage occurred to the glia or nerve cell populations. In accordance with this no effect was seen on acid phosphatase. Plasma butyrylcholinesterase increased 2-fold in exposed male mice while it was unaffected in females. Liver weight in males and females increased with a factor of 1.5 and 1.9, respectively.