ATP: creatine phosphotransferase in the diagnosis of acute chest pain.

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Abstract
The sera of 145 patients presenting with acute chest pain were examined for glutamic oxaloacetate transaminase, a -hydroxybutyrate dehydrogenase, and creatine kinase activities. The transaminase activity was raised in 87%, the dehydrogenase activity in 97%, and the creatine kinase activity in 96% of cases of myocardial infarction. Raised serum enzyme levels were obtained on occasions in other conditions presenting with acute chest pain, but both patients with dissecting aortic aneurysms, and all 5 with severe tachycardia, had raised serum levels of creatine kinase. The view is expressed that though assays of the dehydrogenase and kinase are superior to the glutamic oxaloacetate transaminase as diagnostic aids for cases of myocardial infarction, it is doubtful if there is sufficient improvement to warrant replacing this familiar and well-tried test, which is in current use in most clinical laboratories, by one of the newer techniques.