A Simple, Preparative Procedure forN3-Anisoyluridine andO6-Diphenylcarbamoylguanosine 2′-O-(Tetrahydropyran-2-YL) DerivativesviaThe Corresponding 3′,5′-Dibenzoates
- 1 February 1988
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 7 (1) , 37-43
- https://doi.org/10.1080/07328318808068701
Abstract
3′,5′-Di-O-benzoyl-2′-O-(tetrahydropyran-2-yl)uridine and 3′,5′ -di-O-benzoyl-N 2-isobutyryl-2′-O-(tetrahydropyran-2-yl)guanosine are converted into-N 3-anisoyl-2′-O-(tetrahydropyran-2-yl)uridine (less and more polar diastereoisomers in 37% and 42% yields, respectively) and O 6-diphenyl carbamoylN 2-isobutyryl-2′-O-(tetrahydropyran-2-yl)- guanosine (less and more polar diastereoisomers in 15% and 59% yields, respectively), respectively, by N 3-anisoylation and O 6-diphenylcarbamoylation, followed by 3′,5′-di-O-debenzoylation.This publication has 4 references indexed in Scilit:
- Chemical Synthesis of Capped Oligoribonucleotides, m7G5′ pppAUG and m7G5′ pppAUGACCBulletin of the Chemical Society of Japan, 1985
- Synthesis of a dodecaribonucleotide, GUAUCAAUAAUG, by use of "fully" protected ribonucleotide building blocksJournal of the American Chemical Society, 1984
- 3-N-Acyl Uridines: Preparation and Properties of a New Class of Uracil Protecting Group.Acta Chemica Scandinavica, 1983
- Conversion of guanosine into its N 2-methyl derivativeJournal of the Chemical Society, Chemical Communications, 1977