Minireview: Constitutively Active G Protein-Coupled Receptors: Potential Mechanisms of Receptor Activation
- 1 January 1997
- journal article
- review article
- Published by Taylor & Francis in Journal of Receptors and Signal Transduction
- Vol. 17 (1-3) , 57-73
- https://doi.org/10.3109/10799899709036594
Abstract
Mutations of G protein-coupled receptors can increase their constitutive (agonist-independent) activity. Some of these mutations have been artificially introduced by site-directed mutagenesis, others occur spontaneously in human diseases. The analysis of the constitutively active G protein-coupled receptors has provided important informations about the molecular mechanisms underlying receptor activation and drug action.Keywords
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