Unresponsiveness to a foreign antigen can be caused by self-tolerance
- 1 November 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 336 (6196) , 222-225
- https://doi.org/10.1038/336222a0
Abstract
In mice, two sets of genes govern the immune response to the synthetic antigen GT. One maps to the major histocompatibility complex and behaves like a typical immune response gene. The second is a background gene encoding a cell surface structure found on B cells. Mice which express, and are therefore tolerant of, one form of this structure do not respond to GT. Thus, tolerance of self generates holes in the T-cell repertoire, partially crippling the immune system.Keywords
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