Abstract
The labelled guanine precursors [14C]formate, [1-l4C]glycine, [2-14C]glycine, [8-14C]hypoxanthine, and [3H]inosine monophosphate are actively incorporated or converted into guanine excreted by Dermacentor andersoni (lxodidae) and Argas (Persicargas) arboreus (Argasidae). Hypoxanthine is converted to the greatest extent: 92.8 ± 1.4% (±SE) in D. andersoni and 91.3 ± 1.0% (±SE) in A. (P.) arboreus. This radioactivity distribution pattern in species of the 2 major tick families suggests that ticks synthesize guanine by a metabolic pathway similar to that in other animals and from the same precursors.

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