Prostaglandin H synthase-dependent epoxidation of aflatoxin B1
- 1 January 1985
- journal article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 6 (8) , 1227-1229
- https://doi.org/10.1093/carcin/6.8.1227
Abstract
This report demonstrates that aflatoxin B1 (AFB1) is cooxidized by prostaglandin H (PGH) synthase to form 2,3-dihydro-2,3-epoxy-aflatoxin B1 oxide. Using ram seminal vesicle microsomes as a source of PGH synthase, our results demonstrate that AFB1 is converted to a mutagen during arachidonate turnover that we identify as the epoxide by isolating adducts formed to DNA. The efficiency of AFB1 epoxidation by PGH synthase is assessed and compared with mixed-function oxidase-dependent metabolic activation of this compound.Keywords
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