Differential effects of interleukin-1α and β on the arachidonic acid cascade in human synovial cells and chondrocytes in culture

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Abstract
The effects of interleukin-1α and β were tested on the [3H]-arachidonic acid release and the prostaglandin synthesis by human cultured synovial cells and chondrocytes. Both forms of interleukin-1 stimulated the arachidonic acid release but interleukin-1β was more potent than IL-1α. Human synovial cells and chondrocytes synthesized three types of prostaglandins upon stimulation with interleukin-1α or β: prostaglandin E2, F2α and 6-keto-prostaglandin F1α. Regarding the synthesis of these prostaglandins, IL-1β was again more potent than IL-1α. A comparison between interleukin-1-stimulated synovial cells and chondrocytes revealed neither significant quantitative nor qualitative differences in both the arachidonic acid release and the prostaglandin synthesis.