Antiallergic activity of tetracyclic derivatives of quinoline-2-carboxylic acids. 1
- 1 September 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 21 (9) , 984-988
- https://doi.org/10.1021/jm00207a026
Abstract
Substitution of 1,4-dihydro-4-oxoquinoline-2-carboxylic acid by acetyl, benzoyl and phenylsulfonyl substituents enhanced activity in the rat passive cutaneous anaphylaxis assay. A further increase in activity to equipotency with DSCG [disodium cromoglycate] was achieved by incorporation of 8-benzoyl moiety into a tetracyclic structure to give 1,4-dihydro-4,11(1H,11H)-dioxoindeno[1,2-h]quinoline-2-carboxylic acid. In contrast, the reverse isomer had little activity.This publication has 1 reference indexed in Scilit:
- (2-Carboxy-1,4-dihydro-4-oxoquinolyl)oxamic acids and (2-carboxy-1,4-dihydro-4-oxobenzo[h]quinolyl)oxamic acids as antiallergy agentsJournal of Medicinal Chemistry, 1977