Approaches to the assembly of the antifungal agent FR-900848: studies on double asymmetric cyclopropanation and an X-ray crystallographic study of (1R,2R)-1,2-bis-[(1S,2S)-2-methylcyclopropyl]-1,2-ethanediyl 3,5-dinitrobenzoate

Abstract
Double asymmetric Simmons–Smith cyclopropanation and Whitham elimination were used to prepare (E)-1,2-bis-[(1S,2S)-2-methylcyclopropyl]ethane, the dicyclopropylethene unit of FR-900848.

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