Enzymatic Synthesis of 2′,3′-Dideoxyguanosine
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (10) , 753-754
- https://doi.org/10.1055/s-1991-34774
Abstract
2′,3′-Dideoxyguanosine (ddG) can be conveniently synthesized in very high yields by utilizing the hydrolase activity of the ubiquitous mammalian enzyme, adenosine deaminase (ADA). The immediate precursor in this synthesis is 2-amino-6-chloro-2′,3′-dideoxypurine nucleoside, which is readily prepared from guanosine.Keywords
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