Puberty Acceleration in Mice. I. Dose-Response Effects and Lack of Critical Time Following Exposure to Male Mouse Urine

Publisher Website
Google Scholar
Abstract
Hybrid (SJL x SWR)F1 mice were used as the experimental animals in a uterine weight bioassay for puberty-accelerating pheromone of male mice. The bioassay was characterized with respect to age and weight of female mice, time factors and mode of pheromone administration. Advantages over previously used assays are: optimal assay time is short (48 h); a single application of male urine to the oronasal groove provides sufficient stimulus; and there is no seasonal variation.