Predicting human safety: screening and computational approaches
- 1 October 2000
- journal article
- Published by Elsevier in Drug Discovery Today
- Vol. 5 (10) , 445-454
- https://doi.org/10.1016/s1359-6446(00)01559-2
Abstract
No abstract availableKeywords
This publication has 38 references indexed in Scilit:
- The discovery–development interface has become the new interfacial phenomenonDrug Discovery Today, 1999
- Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in ratsDrug Discovery Today, 1999
- High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compoundsCurrent Opinion in Chemical Biology, 1998
- New assay technologies for high-throughput screeningCurrent Opinion in Chemical Biology, 1998
- Managing the drug discovery/development interfaceDrug Discovery Today, 1997
- Preclinical Drug Metabolism in the Age of High-Throughput Screening: An Industrial PerspectivePharmaceutical Research, 1997
- Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver SlicesDrug Metabolism Reviews, 1997
- Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsAdvanced Drug Delivery Reviews, 1997
- Success rates for new drugs entering clinical testing in the United StatesClinical Pharmacology & Therapeutics, 1995
- Prediction of the maximal tolerated dose (MTD) and therapeutic effect of anticancer drugs in humans: integration of pharmacokinetics with pharmacodynamics and toxicodynamicsCancer Treatment Reviews, 1995