Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation
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- 1 October 2007
- journal article
- review article
- Published by Taylor & Francis in Expert Review of Vaccines
- Vol. 6 (5) , 685-698
- https://doi.org/10.1586/14760584.6.5.685
Abstract
Aluminum-containing adjuvants are an important component of many vaccines because they safely potentiate the immune response. The structure and properties of aluminum hydroxide adjuvant, aluminum phosphate adjuvant and alum-precipitated adjuvants are presented in this review. The major antigen adsorption mechanisms, electrostatic attraction and ligand exchange, are related to the adjuvant structure. The manner by which aluminum-containing adjuvants potentiate the immune response is related to the structure, properties of the adjuvant and adsorption mechanism. Immunopotentiation occurs through the following sequential steps: inflammation and recruitment of antigen-presenting cells, retention of antigen at the injection site, uptake of antigen, dendritic cell maturation, T-cell activation and T-cell differentiation.Keywords
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