INFLUENCE OF CASTRATION AND SEX HORMONE ADMINISTRATION ON THE SENSITIVITY OF RAT ADIPOSE TISSUE TO INSULIN

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Abstract
SUMMARY: Sensitivity of adipose tissue to insulin from normal, castrated, castrated and testosterone-treated or castrated and oestradiol-treated rats of both sexes has been studied, using the manometric method for measuring fatty tissue activity in vitro. Castration in males decreased the volume of CO2 produced by epididymal fat when insulin was added in vitro. Administration of testosterone to castrated males restored normal sensitivity, and oestradiol increased the sensitivity to insulin above normal values. Neither castration nor testosterone administration to spayed females produced statistically significant changes.