Bioactive Marine Alkaloids
- 1 July 2000
- journal article
- Published by Bentham Science Publishers Ltd. in Current Organic Chemistry
- Vol. 4 (7) , 765-807
- https://doi.org/10.2174/1385272003376085
Abstract
The structures, origins, biogenesis, synthesis and bioactivity of a selection of N-heterocyclic marine alkaloids are reviewed. The emphasis is on compounds poised as potential anticancer drugs: lamellarins (pyrroles), cephalostatins/ritterazines (pyrazines) and ecteinascidins (isoquinolines). Also discussed are examples of bioactive marine alkaloids that have emerged as novel leads. These include manzamines (β-carbolines), variolins (pyridopyrrolopyrimidines) and the pyrroloquinoline family. This review emphasises the role of marine alkaloids as an important source of leads for drug discovery.Keywords
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